Abstract
Objective:The aim of this study is to investigate the relationship between the expression of Survivin and Aurora-b in laryngeal carcinoma and its clinical and pathological features, and to determine the possibility of Survivin and Aurora-b being a biomarker in laryngeal carcinoma diagnosis or being an predictor of overall survival (OS) in laryngeal carcinoma patients underwent surgical resection. Method:Eighty-six cases of laryngeal carcinoma tissues diagnosed by pathology were collected, and 86 cases of adjacent tissues and 22 cases of normal tissues were selected as control. The expression of Survivin and Aurora-b were detected by immunohistochemistry in laryngeal carcinoma, adjacent tissues and normal tissue. Result:Survivin and Aurora-b in laryngeal carcinoma were significantly higher than those in adjacent tissues and normal tissues (P<0.01). The expression of Survivin protein was correlated with clinicopathological features such as lymph node metastasis and recurrence (P<0.05), but it was not related to the pathological features such as age, sex, clinical stage and differentiation. The expression of Aurora-b was correlated with the pathological grade clinical stag (TNM stage) and recurrence in laryngeal carcinoma (P<0.05). Survival curves show Survivin and Aurora-b in laryngeal cancer is associated with prognosis of laryngeal carcinoma. The result of COX regression analysis show that the expression of Aurora-b and recurrence are independent prognostic risk factors for postoperative patients with laryngeal carcinoma (P<0.05), while Survivin and lymph node metastasis are not independent prognostic factors influencing prognosis. Conclusion:Our study shows that Survivin and Aurora-b and their interaction may play an important role in the metastasis and prognosis of laryngeal carcinoma. The expression levels of Survivin and Aurora-b might be biomarkers for laryngeal carcinoma diagnosis and an independent predictor of OS after surgical resection, which would provide a novel insight into diagnosis and therapy of laryngeal carcinoma.
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Schedule a callMore From: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
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