The Effectiveness of Various Salacca Vinegars as Therapeutic Agent for Management of Hyperglycemia and Dyslipidemia on Diabetic Rats.

Elok Zubaidah,Dianawati Dianawati,Tiara Puspitasari,Widya Dwi Rukmi Putri,Umi Kalsum

doi:10.1155/2017/8742514

Elok Zubaidah, Dianawati Dianawati + Show 3 more

Open Access

https://doi.org/10.1155/2017/8742514

Copy DOI

Abstract

The aim of this study was to explore the potency of salacca vinegar made from various Indonesian salacca fruit extracts as therapeutic agent for hyperglycemia and dyslipidemia for STZ-induced diabetic rats. The rats were grouped into untreated rats, STZ-induced diabetic rats without treatment, and STZ-induced diabetic rats treated with Pondoh salacca vinegar, Swaru salacca vinegar, Gula Pasir salacca vinegar, Madu salacca vinegar, or Madura salacca vinegar. Parameter observed included blood glucose, total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG), malondialdehyde (MDA), superoxide dismutase (SOD), and pancreas histopathology of the samples. The results demonstrated that all salacca vinegars were capable of reducing blood sugar (from 25.1 to 62%) and reducing LDL (from 9.5 to 14.8 mg/dL), TG (from 58.3 to 69.5 mg/dL), MDA (from 1.1 to 2.2 mg/dL), and TC (from 56.3 to 70.5 mg/dL) as well as increasing HDL blood sugar of STZ-induced diabetic Wistar rats (from 52.3 to 60 mg/dL). Various salacca vinegars were also capable of regenerating pancreatic cells. Nevertheless, the ability of Swaru salacca vinegar to manage hyperglycemia and dyslipidemia appeared to be superior to other salacca vinegars. Swaru salacca vinegar is a potential therapeutic agent to manage hyperglycemia and dyslipidemia of STZ-induced diabetic rats.

Highlights

Diabetes as one of metabolic diseases can be a major cause of complication such as “blindness, kidney failure, heart attack, and stroke” and leads to severe devastation on body’s coordination such as nervous tension and blood vessels [1, 2]
We explored the potency of salacca vinegars made from various types of Indonesian salacca namely, Pondoh, Gula Pasir, Madura, Madu, and Swaru as a therapeutic agent for hyperglycemia and hyperlipidemia of STZ-induced diabetic rats
The daily consumption of salacca vinegar from diverse salacca fruits by STZ-induced diabetic rats indicated their capability as a therapeutic agent for hyperglycemia and hyperlipidemia as demonstrated by blood glucose level, Table 4: Lipid profile of diabetic rats treated with or without various salacca vinegars

Summary

Introduction

Diabetes as one of metabolic diseases can be a major cause of complication such as “blindness, kidney failure, heart attack, and stroke” and leads to severe devastation on body’s coordination such as nervous tension and blood vessels [1, 2]. About 1.5 million deaths were because of diabetes and another 2.2 million deaths were likely due to high blood glucose [3]. Healthy lifestyle, and drug treatment are crucial to manage patients with diabetes. Vinegar was effective in reducing blood sugar and regenerating the pancreas β cells of diabetic Wistar rats and was capable of decreasing LDL, triglycerides, and MDA as well as increasing HDL in their blood glucose [6, 7]. Consumption of vinegar by diabetic patients positively affected insulin activity resulting in a controllable blood sugar [6]

Objectives

Findings

Methods

Conclusion