Abstract
The need for nutrients intake during pregnancy is very important to determine the quality of a child in the future. Several micronutrients take a key role for stimulating the immune system . Zinc is the most important one. This study aims to evaluate the effect of multi micronutrient (MMN) on immunoglobulin G levels of the anemic pregnant women in Second trimester, compared to iron folic acid (IFA). A single blind randomized controlled trial was conducted in Surabaya City. The samples size of 30 pregnant women were randomly allocated into two groups or 15 pregnant women in each group. Control group received iron folic acid , and the treatment group received multi micronutrient UNIMMAP formula. Either IFA or MMN was consumed daily for one month. Statistics analysis was done using Chi square test on data (age, education, income), paired t test , independent t test and the data are not normally distributed then use Mann Whitney. The results showed no significant difference in immunoglobulin G level between the two groups. It can be concluded that the administration of multiple micronutrients (MMN) cannot increase immunoglobulin G in pregnant women with anemia, this is probably due to consumption of macro nutrients that are poor compared to daily needs during pregnancy. 
Highlights
The period of pregnancy is a very important period because at this time the quality of a child is determined
The immune complex consisting of cell and antibody binding to the Fc receptor on the killer cell initiates a cytolytic response aimed at cell-enveloped antibodies
This study aims to find out the effect of multi-micronutrient administration compared with iron fo Acid (IFA) to the levels of immunoglobulin G in anemic second trimester pregnant women
Summary
The period of pregnancy is a very important period because at this time the quality of a child is determined. Fulfillment of optimal nutrition at this time will affect the growth and development of the fetus as well as the health of the mother, if the nutritional intake of pregnant women is not sufficient, there is a possibility that growth disorders will occur in the mother and the fetus she is carrying and a decrease in the immune system in the body(1). Multi micronutrients contain 15 types of vitamins and minerals that are most important for pregnant women including vitamin A, vitamin E, vitamin D, vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, folic acid, vitamin C, Fe, zinc, copper, selenium, and iodine. This study aims to find out the effect of multi-micronutrient administration compared with iron fo Acid (IFA) to the levels of immunoglobulin G in anemic second trimester pregnant women
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