The effectiveness of using mesodiencephalic modulation in combination with ozone therapy in patients with peri-implantitis according to long-term results of the study

Abstract

BACKGROUND: Evaluation of the clinical effectiveness of the use of various treatment regimens for peri-implantitis should take into account not only the immediate results achieved during treatment, but also the manifestations of the disease in the long-term period. AIM: Assessment of the effectiveness of the integrated use of mesodiencephalic modulation (MDM therapy) and ozone therapy in patients with dental peri-implantitis based on long-term results of the study. MATERIALS AND METHODS: The study was carried out with the participation of 116 patients with peri-implantitis of classes I and II according to S.A. Jovanovic. Using the fixed randomization method, all patients were divided into 4 groups based on the results of generating random numbers obtained using a computer program. Patients of the first group (control group, n=28) received standard dental therapy, including professional oral hygiene and local use of antiseptics. Patients of the second group (comparison group 1; n=29) received a course of ozone therapy in addition to standard dental therapy, for which the periimplant area was irrigated with ozonated saline solution with an ozone concentration of 2.5–5.5 μg/ml for 15 minutes. Patients of the third group (comparison group 2; n=30) received a course of MDM therapy in addition to standard dental therapy. In the fourth group (main group; n=29), patients, along with standard dental therapy, received a course of complex physiotherapy in the form of a combination of ozone and MDM therapy. Long-term results of complex therapy for peri-implantitis were assessed 6 and 12 months after the end of treatment. RESULTS: A comparative assessment of dental indices in the long-term period showed that the addition of SST with a course of physiotherapeutic effects, in general, is accompanied by the preservation of the effect achieved after the end of treatment. At the same time, the best results were noted in the main group with the combined use of ozone and MDM therapy. Changes in the osseointegration index also indicated the preservation of the values achieved after the end of therapy, and in the main group a significant increase in this parameter was observed, which indicated additional activation of osseointegration processes under the influence of the physiotherapeutic complex. CONCLUSION: The results of the performed follow-up study convincingly prove the advantages of the additional use of therapeutic physical factors (MDM therapy, ozone therapy and their combination).