The effectiveness of the use of a specialized formula based on hydrolyzed milk protein in children older than 1 year of age with cystic fibrosis

Abstract

Introduction. Malabsorption syndrome is one of the most common manifestations of intestinal insufficiency in cystic fibrosis (CF). CF being the cause of protein-energy malnutrition, so diet therapy using specialized enteral nutrition products is an integral part of CF complex treatment. Purpose. Evaluation of the tolerability and effectiveness of the domestic specialized semi-elemental formula based on hydrolyzed milk protein «NUTRIEN® Elemental» in the treatment of protein-energy malnutrition in CF children older than 1 year of age with malabsorption syndrome. Materials and methods. Under supervision were 32 CF one year 3 months to 17-year children with a mixed form of the disease and malnutrition. Twelve (38%) children had hypolactasia. Nutritional status was assessed using the WHO-Anthro for 1-5-year children and WHO-Anthro Plus for patients over 5 years of age) programs, and indices of clinical and biochemical blood tests. The average duration of follow-up was 21 day. Statistical processing was performed using « Statistica 6.0» («StatSoft Inc.», USA) and Microsoft Excel 2010. Results. While taking a specialized product, there was a decrease in the number of patients with severe and moderate forms of protein-energy malnutrition, a significant upward trend in such biochemical markers of nutritional status as prealbumin (p < 0.01), transferrin (p < 0.01), total protein (p < 0.01). Conclusion. The use of a domestic specialized product based on hydrolyzed milk protein «NUTRIEN® Elemental» in the diet therapy of sick children with malabsorption syndrome, including CF patients, indicates its positive effect on the indices of the nutritional status of patients and the course of the underlying disease.