Abstract
Introduction: Lower urinary tract symptoms (LUTS) due to Benign Prostatic Hyperplasia (BPH) is a common condition in the ageing male. The first-line treatment of LUTS due to BPH is medical management with α-blockers or 5α-reductase inhibitors (5-ARIs). This study aims to analyze the effectiveness of tamsulosin to improve patients symptoms with LUTS due to BPHMethods: A cohort retrospective study was conducted among 62 respondents with BPH at dr. Soetomo Hospital and Airlangga University Hospital from 2014-2016. The data collected related to characteristics of patients were age, prostate volume, Prostate-Specific Antigen (PSA), IPSS score, IPSS voiding score, IPSS storage score, IPSS quality of life, Qmax, voided volume and post voiding residual urine (PVR). All of the data were analyzed using SPSS version 17.0 for Windows.Results: There were 62 samples with a mean age of 62.28 ± 7.3 years old. The average prostate volume was 36.09 ± 8.3 cc, and the PSA level was 2.8 ± 1.45 ng/dl. Most of the respondents were in moderate LUTS criteria (54.8%). IPSS and Qmax score significantly improved in a comparison between pre-treatment, 1 month and 3 months after treatment (p<0.01). There was no adverse event or severe side effect reported.Conclusion: Tamsulosin 0.4 mg daily resulted in statistically significant improvements of IPSS score, IPSS storage score, IPSS voiding score, IPSS Quality-of-life score, Qmax, Voided Volume and PVR through 1 month, but it also significantly improved IPSS score and uroflowmetry results in 3 months after treatment.
Highlights
Lower urinary tract symptoms (LUTS) due to Benign Prostatic Hyperplasia (BPH) is a common condition in the ageing male
Tamsulosin 0.4 mg daily resulted in statistically significant improvements of IPSS score, IPSS storage score, IPSS voiding score, IPSS Quality-of-life score, Qmax, Voided Volume and post voiding residual urine (PVR) through 1 month, but it significantly improved IPSS score and uroflowmetry results in 3 months after treatment
We found that 22.6 % of the patients has mild LUTS, 54.8 % was moderate LUTS and 22.6 % was severe LUTS. (Table 1)
Summary
Lower urinary tract symptoms (LUTS) due to Benign Prostatic Hyperplasia (BPH) is a common condition in the ageing male. The first-line treatment of LUTS due to BPH is medical management with α-blockers or 5α-reductase inhibitors (5-ARIs). This study aims to analyze the effectiveness of tamsulosin to improve patients symptoms with LUTS due to BPH Methods: A cohort retrospective study was conducted among 62 respondents with BPH at dr. Benign Prostatic Hyperplasia (BPH) and Lower urinary tract symptoms (LUTS) are progressive diseases. Treatment of LUTS patients due to BPH using α-blockers as monotherapy or in combination with 5α-reductase inhibitors (s-ARIs) is the firstline therapy.[1] LUTS prevalence caused by BPH increases along with age, moderate to severe LUTS symptoms occur in 40% man aged 60 years.[2]. Some guidelines recommend treatment with alphablockers and 5-alpha reductase inhibitors (5ARI), as monotherapy or combined as appropriate treatment.[3]
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