The Effectiveness of Parecoxib on Inflammatory Cytokines, Prostaglandin Levels, and Visual Analogue Scale Value among Preeclamptic Patients that Undergo Caesarean Section

Abstract

Introduction: Preeclampsia is produced by the maternal immune system and trophoblast proinflammatory cytokines. Effective perioperative analgesics reduce surgery-related pain and inflammation. It explores how parecoxib affects IL-1, IL-6, prostaglandin and VAS in preeclampsia patients who had a spinal anesthesia cesarean. Materials and methods: This experiment uses a 2-group pretest and posttest. Samples were taken consecutively. The study group (n = 18) received parecoxib 40 mg IV bolus every 12 h 4 times and paracetamol 1,000 mg IV infusion every 8 h until 48 h postoperatively, while the control group (n = 18) received placebo NaCl 0.9 % IV bolus every 12 h 4 times and paracetamol 1,000 mg IV drip every 8 to 48 h. Participants’ postoperative pain was assessed by VAS before, 12, 24 and 36 h after surgery. Statistical analysis was conducted on biomolecular examination data, including IL-1β, IL-6, PGE2 and VAS values. Results and discussion: The study group had lower IL-1β levels than the control group, although the difference was not significant (p > 0.05). In the study group, IL-6 levels were 4,782 ± 5,673 lower than in the control group (6,147 ± 5,957). Study group IL-6 levels were higher than control group values, although not significantly (p > 0.05). The study group had lower PGE2 than the control group, but not significantly (p > 0.05). The study group’s mean VAS value was 1.722 ± 1.994, lower than the control group’s 1.833 ± 2.007 and not significant (p > 0.05). The study group had considerably lower VAS values than the control group (p < 0.05). Conclusions: In preeclampsia patients who underwent caesarean delivery under spinal anesthesia, parecoxib administration influences IL-1β levels after 24 h and VAS values after 12 h. It did not affect IL-6 or PGE2 levels in preeclamptic individuals who had spinal anesthesia caesarean sections. HIGHLIGHTS Parecoxib, a powerful analgesic, anti-inflammatory drug and moderately toxic maternal and newborn drug Parecoxib has the ability to reduce IL-1β levels after 24 h in preeclampsia patients undergoing cesarean section with spinal anesthesia After 12 h, parecoxib has an effect on the pain scale (VAS) values of preeclampsia patients who underwent a caesarean section under spinal anesthesia GRAPHICAL ABSTRACT