Abstract
Problem statement: The widespread use of insecticides had resulted in insecticide resistance of vectors of dengue as well as polluting the environment. Organotin (IV) compounds had the potential to be developed as the insecticides to overcome the existing problem. Approach: The aim of this study was to examine the insecticidal effects which were larvicidal and adulticidal effects of organotin (IV) benzylisopropyldithiocarbamate compounds against Aedes Aegypti Linn. In laboratory larvicidal bioassay test of a series of three organotin (IV) benzylisopropyldithiocarbamate compounds on third instar larvae of Aedes Aegypti had been carried out. Results: The study was found that compound B showed the best larvicidal effect with the LC50 and LC90 values of 0.004 ppm and 0.007 ppm, respectively. Compound C was also displayed good larvicidal effect with the LC50 and LC90 values of 0.029 ppm and 0.108 ppm, respectively. While, compound A was shown the least larvicidal effect with the LC50 and LC90 values of 0.404 ppm and 0.749 ppm, respectively. Further testing was conducted on compound B on adults of Aedes ageypti female to investigate its adulticidal property. The result showed that compound B displayed good adulticidal activity with LC50 dan LC90 of 4.277 ppm and 27.653 ppm, respectively. Conclusion: Compound B is the most effective compound among three organotin (IV) benzylisopropyldithiocarbamate compounds tested against the dengue vector Aedes Aegypti and has potential to be explored as an insecticide to control the spread of dengue fever.
Highlights
Dengue fever is a mosquito-borne disease that threatens international public health
Aedes Aegypti and Aedes albopictus is the main vector of this disease, but the Aedes Aegypti is the most efficient vector of dengue fever since it live in the house and surrounding houses (Rohani et al, 1997)
We report the insecticidal activity of three compounds of organotin (IV) bezylisopropyldithiocarbamate that were dimethyltin (IV), dibutyltin (IV) and triphenyltin (IV) benzylisopropyldithiocarbamate against Ae. aegypti mosquito in laboratory
Summary
Larvae and adult mosquito: The Aedes Aegypti mosquito larvae and adult mosquitoes were obtained from the colonies that had been reared continuously for generations in a laboratory free of exposure to pathogens and insecticides They were maintained at 25-30°C and 80-90% relative humidity under a Adulticidal bioassay testing: Further testing on the adulticidal activity of the most effective compound in the larvicidal bioassay testing was conducted on adults of Ae. aegypti female. A solution containing distilled water and DMSO, but without the compound solution, served as a negative control and malathion was used as a positive control for comparison. Both groups were treated in a similar manner to that treated group. Three replicates were carried out with mosquitoes from different rearing batches and the results were pooled
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