Abstract
Introduction Depression is one of the most important psychiatric disorders, and the rate of recurrence is high. The heavy cost burden of depression is probably due to treatment-resistant depression. The purpose of this study was to determine the effectiveness of mindfulness-based cognitive therapy (MBCT) in patients with treatment-resistant depression (TRD). Method The present study was a quasi-experimental study conducted with twenty-four patients with treatment-resistant depression. Participants were selected by purposive sampling and randomly assigned to two groups, an experimental group and a control group. The experimental group received MBCT and antidepressants, while the control group received antidepressants only. The Hamilton and Beck Depression Inventory, Self-Compassion Scale, Thought Rumination Scale, and Mindfulness Scale were administered. The treatment program was conducted in eight sessions; with a follow-up period of one month subsequent to treatment termination. Data were analyzed using descriptive statistics (mean and standard deviation) and inferential statistics (analysis of variance for repeated measures and Bonferroni's post-hoc test). Results The results showed that MBCT significantly reduced depression and ruminative thinking in the experimental group and also improved mediators such as mindfulness and self-compassion. Patients maintained gains over the one month follow-up period (p < 0.01). Conclusion The present study provides additional evidence for the effectiveness of MBCT for TRD.
Highlights
Depression is one of the most important psychiatric disorders, and the rate of recurrence is high
The primary aim of this study is to determine the effect of mindfulness-based cognitive therapy (MBCT) on treatment-resistant depression (TRD) and secondary objective include to determine the potential mediators of MBCT effects on TRD, including mindfulness, self-compassion, and rumination
The results showed that MBCT reduced depression in the experimental group compared to the control group, which is consistent with the findings of Kingston et al.,[34] Finucane and Mercer,[35] Papageorgiou and Wells,[36] Teasdale et al.,[37] Kenny and Williams,[38] and Alberto Chiesa et al.[39]
Summary
Depression is one of the most important psychiatric disorders, and the rate of recurrence is high. The purpose of this study was to determine the effectiveness of mindfulness-based cognitive therapy (MBCT) in patients with treatment-resistant depression (TRD). Method: The present study was a quasi-experimental study conducted with twenty-four patients with treatment-resistant depression. Results: The results showed that MBCT significantly reduced depression and ruminative thinking in the experimental group and improved mediators such as mindfulness and self-compassion. Depression is one of the most devastating of all psychiatric disorders It is the leading cause of mental and physical problems, affecting more than 300 million people.[1] depression is considered a serious threat to the health of the community and is associated with significant mortality, disability, and economic burden.[2] Epidemiological studies have shown that the prevalence of this disorder is 27%.3. Epidemiological studies have shown that the prevalence of this disorder is 27%.3 Studies show that the prevalence of clinical depression in Iran is higher than in other countries and that women are more likely to be depressed than men.[4,5]
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