The effectiveness of military physical exercise on irisin concentrations and oxidative stress among male healthy volunteers.

Abstract

Background Irisin, a newly discovered hormone, is secreted into the circulation from skeletal muscles in response to physical exercise. The biochemical parameters related to irisin secretion have not been sufficiently investigated yet. The aim of this study was to examine the effectiveness of exercise on the level of irisin and its correlation with biochemical and oxidative stress parameters. Materials and methods In this pre- and post-test observational study, 39 healthy male volunteers from a military training setting were followed up on between September and November 2015. The individuals who were included in this study were between 22 and 27 years old with an average age of 24. Those with inflammatory disorders or chronic diseases such as diabetes mellitus were excluded from the study. The parameters were measured at the baseline, at 4weeks, and at 8weeks of intervention. Results The study found that the systolic and diastolic blood pressures substantially decreased after 8weeks of intervention. The cholesterol-to-HDL ratio and glucose levels were significantly higher at the baseline compared to 8weeks. Total protein and albumin were significantly higher following 4weeks (0.25 and 0.21g/dL) and 8weeks (0.32 and 0.16g/dL), respectively. Meanwhile, total globulin and irisin increased following 8weeks of the intervention by only 0.16g/dL and 0.41μg/mL, respectively. The high sensitivity C-reactive protein (hs-CRP) decreased following 8weeks (-0.81μg/mL). The protein carbonyl (PC) decreased following 4weeks by only 0.34nmol/L. Conclusions This study demonstrated that military training enhanced irisin hormone secretion following 8weeks of military exercise.