THE EFFECTIVENESS OF LESS INVASIVE SURFACTANT ADMINISTRATION IN NEONATES

Abstract

Purpose: To evaluate the effectiveness of less invasive surfactant administration (LISA) in preterm infants and term newborns with acute respiratory distress syndrome. Methods: A comparative study was carried out with 106 preterm infants aged 26 - 32 weeks of gestation and less than 6 hours old at Tu Du Hospital since August 2017 to July 2018. They were diagnosed of respiratory failure due to endothelial disease indicated for surfactant therapy. Among them, 53 children pumped surfactant by less invasive surfactant administration and 53 children pumped surfactant using INSURE technique. Results: The effective rate (FiO2 decreased by more than 20%) in the LISA treatment group was 90.6% (48/53), that is more than one of the INSURE treatment group, it was 71.7% (38/53). The difference is statistically significant with p < 0.05. The effect of FiO2 reduction by more than 20% in the group treated with less invasive surfactant administration was as 3.79 times (1.16 - 14.37) as that one in the group treated with INSURE, the difference was statistically significant with p < 0.05. Conclusion: Less invasive surfactant administration is safe and effective in preterm infants and term newborns with acute respiratory distress syndrome Key words: Less invasive surfactant administration, INSURE, neonate