The Effectiveness of Hemodialysis in case of Intoxication with Pregabalin

Abstract

Although it was originally developed for the treatment of epilepsy, pregabalin has also been used frequently in the management of neuropathic pain and anxiety disorders recently. Owing to its widespread use in this regard, number of the cases reported with regard to both its side-effects and overdose has been escalating dramatically. More specifically, facial rash, dizziness, drowsiness, peripheral edema and weigh gain, hyponatremia and increase in systolic dysfunction especially in the elderly, hepatotoxicity and transient encephalopathy were reported with increasing incidence in the literature. We hereby reported a case of seizure and metabolic acidosis incited by pregabalin overdose, and our aim is to constitute an appeal for the fact that implementation of hemodialysis is a rapid and effective method in the treatment of seizure and metabolic acidosis in case of pregabalin intoxication.