The Effectiveness of Golden Sea Cucumber Ethanol Extract on The Expression of Endoglin in The Maturation Phase of Healing Mice With Traumatic Ulcers

Abstract

<p><strong><em>Background: </em></strong><em>The traumatic ulcer is the most common oral soft tissue lesion that</em><em> cause physiologic dissorder (pain) in patients, so it need a medicine to improving healing processs.</em><em>Stichopus hermanii contains glycosaminoglyca</em><em>ns, omega-3 and other agents</em><em> that accelerate </em><em>wound</em><em> healing. Their influence againts </em><em>signaling cell for proliferation and angiogenic for healing procce. </em><em>Endoglin plays in a number of cellu- lar processes and the elevated expression during wound</em> healing.<em> <strong>Purpose: </strong>Knowing the effectivity of ethanol extract of Stichopus hermanii towards the </em><em>expression on </em><em>traumatic ulcer maturation phase in oral mucosa. </em><strong><em>Materials and Methods:</em></strong><strong><em> </em></strong><em>The research subjects were forty eight wistar rats divided into 6 groups. Traumatic ulcer was made in the center-rat’s-labial-mucosa. The X<sub>1 </sub>group was smeared with sterilized aquades as the control group. The X<sub>2 </sub>wassmeared with 0,2% hialuronic acid, X<sub>3</sub> with 60% ethanol extract, and X</em><em><sub>4</sub></em><em> with 80% ethanol extract. They were smeared once a day during 4 days. On the sixth day, the rat’s labial mucosa was biopsied to make histological preparation in order to study the amount of fibroblast. <strong>Results: </strong>Kruskal-Wallis test showed </em><em>not</em><em> significant difference (p=0,000) after applying Stichopus hermanii extract</em><em> for expression of endoglin in</em><em> <strong>Conclusions: </strong>ethanol extract</em><em>Stichpus hermanii</em><em> </em><em>not</em><em> effective </em><em>for expression of endoglin on </em><em> </em><em>traumatic ulcer </em><em>maturation phase </em><em>in healing procces</em><em>.</em></p><p> </p><p><strong><em>Keywords:</em></strong><strong> </strong><em>Stichopus hermanii, ulcer healing, </em><em>endoglin</em><em> and traumatic ulcer.</em></p><p><strong><em> <strong><em>Correspondence</em></strong><strong><em>:</em></strong><em> </em></em></strong><em><em>Rima Parwati Sari, Bagian Biologi Oral, Fakultas Kedokteran Gigi Universitas Hang Tuah, Arif Rahman Hakim No. 150</em></em><em><em>,</em><em> Surabaya, Email: rima.sari@yahoo.com</em></em></p>