Abstract
Aims/Introduction: Effectiveness of Diamel? on the biochemical variables: fasting blood glucose, postprandial glucose, cholesterol, triglycerides, and glycosylated haemoglobin [HbA1c] in type-2 diabetic patients receiving insulin terapy. Diamel is a natural product composed of trace elements: amino acids, vitamins, cranberry extract, and lettuce extract that have been activated by means of a magnetization process. Materials and methods: Randomized, doubleblind, comparator-controlled clinical trial. A central randomization centre used computer generated tables to allocate treatments. 116 patients suffering from type-2 diabetes mellitus treated with insulin at the Diabetes Care Centre in Pinar del Rio (Cuba), were recruited and randomly. The subjects were separated into two groups: Group A (n = 59), who were administered Diamel and Group B (n = 57) using placebo. The clinical and biochemical variables were assessed for 24 weeks. Results: Two subjects were excluded from the Diamel treatment group during the clinical trial. From the statistical point of view, a significant drop in the levels of the baseline glucose, postprandial glucose, glycated haemoglobin, and triglycerides was observed in the group taking Diamel (Group A). There was observed an increase in insulin requirements and in waist circumference in the subjects of Group B There was not reported any severe or serious adverse reactions during this clinical trial. Conclusion: Diamel (nutritional supplement) together with the administration of insulin in type-2 diabetic patients is useful to optimize the biochemical variables (baseline and postprandial glucose, Hb A1C, plus triglycerides), as well as to prevent the increase of insulin requirements at medium-term.
Highlights
Almost 85% to 95% of whole diabetic population suffers from type 2 Diabetes Mellitus [1]
L. laboratories, is a natural product composed of trace elements: amino acids, vitamins, cranberry extract, and lettuce extract that have been activated by means of a magnetization process which enhances the biological properties of each of every component
Two subjects were excluded from the Diamel treatment group during the clinical trial: one patient got Assessed for eligibility (n = 138)
Summary
Almost 85% to 95% of whole diabetic population suffers from type 2 Diabetes Mellitus [1]. The interaction between genetic and environmental risk factors contributes to the development of this type of diabetes, as they can affect β-cell function and the peripheral insulin sensitivity [2,3,4]. The increase in free radicals inhibits the insulin action and contributes to the deterioration in β-cell function, leading to chronic complications [7,8,9,10,11]. Several authors have carried out studies on natural products having hopeful results [12,13,14]. L. laboratories, is a natural product composed of trace elements: amino acids, vitamins, cranberry extract, and lettuce extract that have been activated by means of a magnetization process which enhances the biological properties of each of every component. Diamel works out on pancreas whereby its components―zinc, arginine and ornithine―help to stimulate the secretion of insulin, while the lettuce extract helps to reduce the gastrointes-
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