Abstract
Background: Dewandaru plant (Eugenia uniflora L.) is a plant contains flavonoids with anti-inflammatory, anti allergy and antioxidant effects that have various clinically proven benefits. Aims: To determine the effectiveness of Dewandaru (Eugenia uniflora L.) leaf crude extract on total IgE levels in Wistar rats with ovoalbumin-induced allergic rhinitis. Methods: This is a true experimental study with randomized post-test only control group design. This study used 28 male Wistar rats randomly divided into 4 groups (n=7 in each group), i.e negative control group (without therapy), 100 mg/kg BW of extract group, 200 mg/kgBW of extract group, and positive control group (mometasone furoate). Rats were sensitized with ovoalbumin intraperitoneally for 14 days followed by intranasal ovoalbumin exposure on 15th day for 14 days with intervention. Nasal symptom score and IgE serum levels were assessed in all groups. Results: There were significant differences in nasal symptoms scores between groups. Nasal symptoms scores were significantly lower in positive control group and treatment group than in negative control group (p
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