Abstract
Review objective/question Objectives The main objectives of this systematic review are: 1. To assess the effectiveness of continuous subcutaneous insulin infusion (CSII) compared to multiple daily injections (MDI) on quality of life in families of children with type 1 diabetes. 2. To determine the clinical effectiveness of CSII compared to MDI in terms of glycaemic control expressed in the levels of glycated haemoglobin (HbA1c) in children. A secondary objective is: 1. To examine the health outcomes of CSII compared to MDI in terms of the episodes of severe hypoglycaemia and diabetic ketoacidosis. Review questions The specific review questions to be addressed are: 1. What is the effectiveness of CSII compared to MDI on quality of life in families of children with type 1 diabetes pertaining to physical, psychological, social and spiritual domains of life? 2. What is the effectiveness of CSII compared to MDI on glycaemic control in children with type 1 diabetes? 3. What is the effectiveness of CSII compared to MDI on reducing the episodes of severe hypoglycaemia and diabetic ketoacidosis in children with type 1 diabetes? Inclusion criteria Types of participants This review will consider all families of patients aged 18 years or below with type 1 diabetes taking insulin treatment. Families of patients who are critically ill or who are pregnant will be excluded. For the purposes of this review, 'family' is defined as “the body of persons who live in one house or under one head”, as per the definition given by the Oxford English Dictionary. Type I diabetes is defined as a metabolic disorder of multiple aetiology characterised by hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from destruction of the beta cells of the pancreas and insulin deficiency. Given the changes in classification and diagnostic criteria for type 1 diabetes over the years, this review will consider studies which based diagnosis on the valid diagnostic criteria for the illness at the time of the study.TRUNCATED AT 350 WORDS
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