Abstract
Bone defects can occur from many causes, including disease or trauma. Bone graft materials (BGMs) have been used to fill damaged areas for the reconstruction of diseased bone tissues since they are cost effective and readily available. However, BGMs quickly disperse around the tissue area, which ultimately leads to it migrating away from the defect after transplantation. We tested chitosan hydrogels as a useful carrier to hold BGMs in the transplantation area. In this study, we synthesized succinylated chitosan (SCS)-based hydrogels with a high decomposition rate and excellent biocompatibility. We confirmed that BGMs were well distributed inside the SCS hydrogel. The SCS-B hydrogel showed a decrease in mechanical properties, such as compressive strength and Young’s modulus, as the succinylation rate increased. SCS-B hydrogels also exhibited a high cell growth rate and bone differentiation rate. Moreover, the in vivo results showed that the SCS hydrogel resorbed into the surrounding tissues while maintaining the BGMs in the transplantation area for up to 6 weeks. These data support the idea that SCS hydrogel can be useful as a bioactive drug carrier for a broad range of biomedical applications.
Highlights
Introduction iationsMajor bone defects commonly occur in clinical settings due to traumatic accidents, metabolic diseases, osteoclastic tumors, or cancer resection [1]
An equivalent amount of Bone graft materials (BGMs) was added to the mixed solution with succinylated chitosan (SCS) and G6P to make a homogeneous composite
These are designated as SCS-LB (BGMs-loaded succinylation rates: low-succinylated chitosan (SCS-L)), SCS-MB (BGMs-loaded SCS-M), and SCS-HB (BGMsloaded SCS-H) for different succinylation rates of SCS
Summary
Major bone defects commonly occur in clinical settings due to traumatic accidents, metabolic diseases, osteoclastic tumors, or cancer resection [1]. These bone defects often lead to serious subsequent infections, complications, and sequelae that can lead to longterm gait disturbance [2]. Demineralized bone matrix (DBM) is a popular bone substitute that is widely used as one of the most common allografts. DBM is a part of the freeze-dried allogeneic bone that is composed of insoluble collagen and protein. It contains a low concentration of bone morphogenetic protein [4]. Some clinicians and patients are still wary of antigenicity and infection due to human
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