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Abstract
Introduction. The perspective direction in therapy of dyslipidemia (DLP) is a complex application of biologycally active substances from marine hydrobionts. Objective. The purpose of research - to compare the lipidcorrective action of preparates based on biologically active substances from marine hydrobionts - fukolam and maristim - individually and in combination with atorvastatin in patients with DLP. Materials and methods. 250patients with DLP and 40 healthy donors were included in research. As medicines atorvastatin, fukolam, maristim were used. In the blood serum the levels of lipid spectrum were determined. Results. Hypolipidemic action of fukolam in complex of basic therapy of patients with DLP was implemented by gradually reducing the total cholesterol, cholesterol of low-density lipoproteins, triglycerides levels to control values. The efficacy of fukolam was comparable with that of atorvastatin in a daily dose of 10 mg. Complex of «fukolam-maristim» showed hypolipidemic effect in severe hyperlipidemia. Conclusions. Combined therapy with use of bioactive substances of natural origin may be one of the way to improve the efficiency of hypolipidemic therapy. We have developed the algorithm of differential correction of DLP by inclusion the fukolam and maristim in complex therapy.
Highlights
The perspective direction in therapy of dyslipidemia (DLP) is a complex application of biologycally active substances from marine hydrobionts
The purpose of research – to compare the lipidcorrective action of preparates based on biologically active substances from marine hydrobionts – fukolam and maristim – individually and in combination with atorvastatin in patients with DLP
Hypolipidemic action of fukolam in complex of basic therapy of patients with DLP was implemented by gradually reducing the total cholesterol, cholesterol of low-density lipoproteins, triglycerides levels to control values
Summary
Запорожец1, 3 1ФГБУЗ «Медицинское объединение Дальневосточного отделения РАН»; Россия, 690022 Владивосток, ул. 95; 2ФГАОУ ВО «Дальневосточный федеральный университет», Школа биомедицины; Россия, 690922 Владивосток, о. Перспективным направлением липидкорригирующей терапии является комплексное применение биологически активных веществ из морских гидробионтов. Цель исследования – сравнительная оценка липидкорригирующего действия фуколама и маристима – препаратов на основе биологически активных веществ из морских гидробионтов – индивидуально и в комплексе с аторвастатином у пациентов с дислипидемией (ДЛП). У пациентов с ДЛП гиполипидемическое действие фуколама на фоне базисной терапии реализуется путем постепенного снижения уровня общего холестерина, холестерина липопротеинов низкой плотности, триглицеридов до контрольных значений. Комбинированная терапия с использованием биологически активных веществ природного происхождения может быть одним из путей повышения эффективности гиполипидемической терапии. Разработан алгоритм дифференцированной коррекции ДЛП путем включения в комплекс лечения фуколама и маристима.
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