The Effectiveness Of Combination Vitamin D With Phototherapy For Vitiligo Treatment

Abstract

Vitiligo represents a pigmentary skin disorder that impacts the layers of the skin, characterized by the absence of pigmentary cells in the epidermis, which causes the body to develop white patches and macules. However, additional research is necessary to comprehensively grasp the mechanisms that can be obtained using vitamin D with phototherapy for vitiligo treatment. Current evidence indicates that vitamin D substantially influences keratinocytes and melanocytes' activities through various mechanisms. Therefore, this literature review was organized to assess the effectiveness of combining vitamin D with phototherapy for vitiligo treatment. A search was conducted across four electronic journal databases: Google Scholar, PubMed, Taylor & Francis, and ScienceDirect. Inclusion criteria involved studies with vitiligo respondents, explaining the effectiveness of combining vitamin D with phototherapy for vitiligo treatment and detailing the benefits or harms of using this combination in vitiligo patients. Only five studies met the specified criteria and are consequently considered deserving of further assessment. The combination of phototherapy and vitamin D is postulated to manage vitiligo effectively. Phototherapy enhances repigmentation, ensuring a harmonious color reconciliation with the innate skin tone. Simultaneously, Vitamin D assumes a pivotal role in modulating the activity of keratinocytes and melanocytes, operating through diverse mechanisms. Based on this article review, it can be concluded that phototherapy with vitamin D is more effective in treating vitiligo than phototherapy only.