Abstract
Aim To study the effectiveness of cochlear implantation in deaf children with gene mutation. Method 420 children from three medical centers with cochlear implants were selected. Before wearing the cochlear implant and 6 months after wearing the cochlear implant, the children's rehabilitation efficacy was evaluated through categories of auditory performance (CAP) and speech intelligibility rating (SIR). The SSF-MCDI and MUSS before and after the treatment were also compared. Results The CAP and SIR scores of the children after the intervention were higher than those before the intervention (P < 0.05). Univariate analysis found that the age of cochlear implantation, parents' education level, and monthly family income were all influencing factors of the CAP score of children with prelingual cochlear implantation (P < 0.05). Multivariate logistic regression analysis shows that the age of cochlear implantation <5 years, parents' education level, and monthly household income are all independent risks of CAP scores in children with prelingual deaf cochlear implantation. Univariate analysis found that the age of cochlear implantation, parents' education level, and monthly household income are all based on the SIR scores of children with prelingual cochlear implantation. Multivariate logistic regression analysis can be obtained: the age of cochlear implantation less than 5 years, the education level of parents, and the monthly family income are independent risk factors for SIR scores in children with prelingual deaf cochlear implantation (P < 0.05). Conclusion The rehabilitation effect of cochlear implants is significant, and the age of cochlear implantation, parents' education level, and monthly family income are all related factors that affect the rehabilitation effect.
Highlights
Hearing impairment is a common birth defect disease of newborns in clinical practice, and its incidence is about 0.1% to 0.2% [1,2,3]. ere are about 23,000 newborns with different degrees of hearing impairment each year [4]. e vast majority are severe sensorineural hearing loss
Inclusion criteria were set as follows: (1) all the included subjects were diagnosed with GJB2 gene mutation deafness; (2) the patients were younger than 7 years; (3) the cochlear implants worn by the patients were of the same size; and (4) the hearing aids were not improved for 3 to 6 months before the operation
Among all patients with GJB2 hereditary deafness, 145 cases were 235delC homozygous mutations, 109 cases were 235delC/299_300delAT compound mutations, 235delC/176del16 compound mutations, 35delG/235delC compound mutations, 235delC/ 512insAACG compound mutations, and 299_300delAT pure, and 235delC mutations were each in 102 cases. ere were 35 cases of/427C-T compound mutation, 35delG/ 299_300delAT compound mutation, and 35delG/605ins46 compound mutation
Summary
Hearing impairment is a common birth defect disease of newborns in clinical practice, and its incidence is about 0.1% to 0.2% [1,2,3]. ere are about 23,000 newborns with different degrees of hearing impairment each year [4]. e vast majority are severe sensorineural hearing loss. Hearing impairment is a common birth defect disease of newborns in clinical practice, and its incidence is about 0.1% to 0.2% [1,2,3]. Ere are about 23,000 newborns with different degrees of hearing impairment each year [4]. E vast majority are severe sensorineural hearing loss. With the popularization and promotion of genetic diagnosis technology, many children with congenital hearing impairment can detect deafness genes. The proportion of GJB2 gene mutations is 26.5% [7]. As the only effective method for the treatment of severe or extremely severe sensorineural hearing loss, have been widely used in clinical practice, and more and more children are benefiting from it
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