The Effectiveness of Cherry LeavesDecoction (Muntingia Calabura L) Towards SGOT SGPT Serum on Male Wistar Rats in Critical Hepatitis Model

Abstract

Critical Hepatitisis is caused by viruses, alchol and drugs which are characterized by theincreasing values of SGOT SGPT. The aim of this study is to determine the effectiveness ofdecoction extracts of cherry leaves (Muntingia Calabura L) towards serum SGOT SGPT onmale wistar rats in critical hepatitis model. The rats that have been used are in number of 30male rats with the weight is 180-200 grams and the age of 2-3 months devide into 3groups,which are negative groups, positive groups and treatment groups.Each groups consistof 10 rats. The negative group is given an usual food and drink. The positive group and thetreatment group are induced with 120 mg/ oral paracetamol for 7 days to increase serum levelsof SGOT SGPT. The treatment group is given a decoction therapy of 10 grams cherry leavesin 100cc of water that is given 3.6cc/oral for 7 days.While the positive group is only given aregular food and drink for 7 days.ANOVA test is conducted to analyze this studyby using SPSS24 version. It is found in the result of the study that there are significant differences in serumlevel of SGOT between the treatment group, positive group and negative group (p<0,05). Thereis a significant value difference of SGPT in the treatment group and the positive group(p<0,05). However, there is no significant difference between the level of SGPT in thetreatment group and the negative group (p=0,121).The conclusion is cherry leaves decoction(Muntingia Calabura L) has an effect towards the decrease of SGOT SGPT serum level onmale wistar rats in critical hepatitis model.