Abstract
Topical tretinoin is used by the dermatolovenereologist and aesthetic physicians in patients with mild acne vulgaris, so it is necessary to be investigated. The aim of the study was to assess the effectiveness of benzoyl peroxide gel compared to tretinoin gel on persons with mild acne vulgaris and identify Propionibacterium acnes in patients with mild acne vulgaris. The research method was a clinical trial, double blind randomization. Patients with mild acne vulgaris were randomized in to 2 groups, each group was examined for clinical manifestations (comedone, papules or pustules) examination with sebumeter 815 and Polymerase Chain Reaction, every night each group was treated with benzoyl peroxide 5% gel and tretinoin 0.05% gel in the application, and followed-up in the days of the week 2, 4 and 6. Data were processed with Mann-Whitney test and Chi-Square Test. The results indicated benzoyl peroxide 5% gel and tretinoin 0.05% gel have the same effectiveness in patients with mild acne vulgaris. But, benzoyl peroxide 5% gel decreased blackheads faster compared to papules or pustules with 0.05% tretinoin gel. of sebum. There was no difference in levels of decrease between benzoyl peroxide 5% gel and tretinoin 0.05% gel. Propionibacterium acnes were found in patients with mild acne vulgaris before the treatment of benzoyl peroxide 5% gel and tretinoin 0.05% gel, although not found in all samples.
Highlights
Acne vulgaris is a self-limited inflammatory skin disease of pilosebaceous gland that usually affects teenagers age group
[6] The findings of this study indicate that from 40 samples of patients with mild acne vulgaris that had been evaluated by PCR, there is no significant difference between groups treated with benzoyl peroxide 5% gel and tretinoin 0.05% gel
It was found that 11 patients in benzoyl peroxide 5% gel group were PCR positive, and 9 patients in tretinoin 0.05% gel group were PCR positive
Summary
Acne vulgaris is a self-limited inflammatory skin disease of pilosebaceous gland that usually affects teenagers age group. Acne is an abnormality especially in teenagers age, even though it can affect all age groups. Acne is formed in hair follicle of the skin, like cells that are buried in skin surface acne is buried in the follicle. The increase of accummulation process together with cohesiveness increase of these cells (hyperkeratotic retention) and increase in sebum production results in the formation of comedone (plugged hair follicle containing sebum, keratin, and normal flora), its content are gathered and begin to form inflammation. The bacteria is known as Propionibacterium acnes naturally appears far in the follicle. This bacteria is not pathogenic it self but contributes to the acne development.
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