Abstract
Otospongiosis is a primary osteodystrophy of the otic capsule that affects genetically predisposed individuals and leads to a progressive hearing loss. AimTo evaluate the applicability of audiometric evaluation during drug treatment for otospongiosis. Materials and MethodsA prospective, randomized, controlled, double-blind study involving 26 patients with clinical, audiometric and CT scan image of otosclerosis. Patients eligible for the study were divided into three groups (A, B and C) and received treatment with alendronate sodium (B), sodium fluoride (C) and placebo (A) for 6 months. After this period they were submitted to new tests. ResultsThere were not statistically significant differences between air and bone conduction (gap). We also found no differences in the speech recognition threshold (SRT) and speech discrimination (IRF) between before and after treatment. ConclusionAfter six months of drug treatment the audiometric evaluation kept the same hearing thresholds, suggesting stabilization of the otospongiotic lesions.
Highlights
IntroductionOtospongiosis is a primary focal osteodystrophy of the ear capsule that affects genetically predisposed individuals and introduces a metabolic disorder on the endochondral layer of the labyrinth bone characterized by resorption and disorganized new bone growth
Otospongiosis is a primary focal osteodystrophy of the ear capsule that affects genetically predisposed individuals and introduces a metabolic disorder on the endochondral layer of the labyrinth bone characterized by resorption and disorganized new bone growth.This disease presents no symptoms in most cases
We found no differences in the speech recognition threshold (SRT) and speech discrimination (IRF) between before and after treatment
Summary
Otospongiosis is a primary focal osteodystrophy of the ear capsule that affects genetically predisposed individuals and introduces a metabolic disorder on the endochondral layer of the labyrinth bone characterized by resorption and disorganized new bone growth. This disease presents no symptoms in most cases. Many theories have been tried to explain the injuries to the inner ear causes by otospongiosis, such as: release of toxic enzymes into the fluids of the inner ear; vascular shunts between otosclerotic sites and labyrinthine vessels; atrophy in the organ of Corti and in the stria vascularis; hyalinization of the spiral ligament; narrowing of the cochlear lumen; distortions in the basilar membrane; and degeneration of cochlear nerve cells[1]. Proteolytic and hydrolytic enzymes are released by lysosomes rupturing inside histiocytes found in the active otospongiosis site, adversely affecting the labyrinthine neuroepithelium[2,3,4,5]
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