Abstract
Objective This study aimed to evaluate the effect of 0.2% chlorhexidine (CHX) gel on wound healing after tooth extraction. Materials and Methods A single blind, randomized controlled trial was performed recruiting 32 participants who underwent dental extractions. Patients were randomly allocated for CHX group or placebo group. The primary outcomes were wound closure measured with calipers and healings were assessed by Landry et al index after 7 days of topical application of allocated gels on extraction sites. Results The wound closures were greater in CHX group compared with placebo group and healing scores were correlated with the use of CHX gel ( p -value < 0.05). Conclusion In a population of healthy nonsmoker adults, application of 0.2% CHX gel twice a day for 7 days after tooth extraction has a beneficial effect on wound healing.
Highlights
Tooth extraction is a very common procedure that dentists perform every single day
In a population of healthy nonsmoker adults, application of 0.2% CHX gel twice a day for 7 days after tooth extraction has a beneficial effect on wound healing
Inclusion criteria of eligible participants were as follows: (1) patients who underwent tooth extraction of mandibular first molar, (2) aged 18 to 50 years with American Society of Anesthesiologists (ASA) physical status I, (3) did not have the medical history of being allergic to CHX and mefenamic acid, (4) was not consuming any other antibiotic, analgesic or anti-inflammation drug(s) at least 7 days prior to the procedure, (5) lack of infection at the tooth indicated for extraction 3 days prior to the extraction procedure, and (6) absence of any pathology at the area of the tooth indicated for extraction and neighboring teeth
Summary
Postoperative complication generally do not occur; occasionally delayed wound healing may arise even in normal healthy patients. The most frequent postextraction complications documented were infection, prolonged bleeding, swelling, as well as dry socket.[1] In addition, patient may experience pain even after a simple uncomplicated tooth extraction.[2,3]. Oral healing is slower and delayed compare with dermal repair.[4] Unlike skin surface, oral environment cannot be sterilized from oral bacteria or plaque formation, leading to persistent environmental challenge for the oral wound. Infection is one of the significant causes of delayed wound healing; early period of healing after tooth extraction must be facilitated and protected from infection or any condition inhibiting healing and repair.[5]
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