The effectiveness and persistence of LTP on synaptic plasticity during sleep and sleep deprivation

Abstract

The synaptic strength, which is crucial for memory and cognition function, is significantly influenced by sleep. According to earlier research, sound sleep is crucial for promoting connections between neural networks that are necessary for memory consolidation in the hippocampus. On the other hand, sleep deprivation can seriously impair the plasticity of our synapses. Sleep deprivation will disrupt LTP in region CA1 of the hippocampus, causing damage to neural connections. LTP has been proven to improve the connection between synapses, which will promote synaptic plasticity and so influence cognition function favorably. We also take a deeper look at LTP from a cellular and genetic perspective. In this review, we explore the detrimental effects of sleep deprivation on LTP stimulation and how they weaken synaptic plasticity and impair memory and learning performance. By studying LTP we can unravel the mysteries of brain function and the ability to learn and memory, and it can also give implications for understanding neurological disorders and advancing our knowledge of neurol system.