Abstract

Three groups of SPF Wistar rats were fed on radiation-sterilized, autoclave-sterilized and ordinarily autoclave-treated SPF food, respectively. All females were autopsied 15-17 days after the mid-week of presumptive mating. Corpora lutea, deciduomata, dead and living embryos were counted. The induction of dominant lethal mutations was evaluated by comparing the ratio of living embryos with the number of corpora lutea in the three groups. No indication of dominant lethal mutations being induced in the group fed on radiation-sterilized feed has been found.

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