The effect on intravenous and intra-articular cavity injection of tranexamic acid on recessive loss of blood in primary total knee arthroplasty

Abstract

Objective The effection of tranexamic acid in recessive loss of blood in primary total knee arthroplasty. Methods One hundred patients having primary total knee arthroplasty were randomly divided into 2 groups, the tranexamic acid group and the control group, with 50 patients in each.the groups, 0.5 g tranexamic acid was infused intravenously within 15 minutes befor skin incision, before deflation of the tourniquet, the tranexamic acid group accepted 0.5 g tranexamic acid and 25 ml intra-articular cavity injection of tranexamic acid intravenously, while an equal volume of normal saline was given instead in the control group.After 2 days, respectively calculate the total amount of blood loss, intraoperative blood loss, postoperative drainage, hidden blood loss and transfusion rates. Results The total amount of blood loss tranexamic acid group and the control group, after the replacement of drainage, hidden blood loss and transfusion rate in the ranexamic acid group were (0.326±0.221) L, (0.048±0.018) L, (0.210±0.113) L, (0.231±0.176) L, 19%, lower than the control group (1.012±0.520) L, (0.056±0.012) L, (0.402±0.231) L, (0.532±0.514) L, 65%, the difference were statistically significantstatistically significant (P<0.05). Conclusion The effects are remarkable in reducing knee arthroplasty hidden blood loss about tranexamic acid. Key words: Primary total knee arthroplasty; Tranexamic acid; Recessive loss of blood; Intravenous; Intra-articular cavity injection