Abstract
Background: Several studies have previously been performed to promote kidney healing after injuries. Objectives: The aim of this study was to investigate the effect of zinc on renal healing after traumatic injury in rats. Materials and Methods: Forty healthy female rats were selected and one of their kidneys was incised. Half of the incisions were limited only to the cortex (renal injury type I) and the other ones reached the pelvocalyceal system of the kidney (renal injury type II). All the rats in the zinc treated group (case group) received 36.3 mg zinc sulfate (contained 8.25 mg zinc) orally. After 28 days, the damaged kidneys were removed for histopathological studies. Results: In the rats with type I injury, kidney inflammation of the case group was significantly lower than that of the control group. However, the result was not significant in rats with type II injury. Tissue loss and granulation tissue formation were significantly lower in the case group than the control group in both type I and II kidney injuries. Conclusions: Overall, Zinc can contribute to better healing of the rat’s kidneys after a traumatic injury.
Highlights
Wound healing is a biological survival mechanism which starts immediately after destruction of the tissue or skin integrity
In the control group, 4 rats had 1-3 mm and 3 had more than 3 mm tissue loss, which was statistically significant compared with zinc treated rats
Granulation tissue formation was significantly lower in the case groups than the control groups in both type I and II injury (Table 1)
Summary
Wound healing is a biological survival mechanism which starts immediately after destruction of the tissue or skin integrity. This process consists of three main phases: inflammation, proliferation and tissue remodeling [1]. Objectives The aim of this experimental study was to investigate the effect of zinc on renal wound healing. Objectives: The aim of this study was to investigate the effect of zinc on renal healing after traumatic injury in rats. Results: In the rats with type I injury, kidney inflammation of the case group was significantly lower than that of the control group. Tissue loss and granulation tissue formation were significantly lower in the case group than the control group in both type I and II kidney injuries. Conclusions: Overall, Zinc can contribute to better healing of the rat’s kidneys after a traumatic injury
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