The effect of zearalenone on some enzymatic parameters in rabbits

Abstract

The effects of low (10 μg/kg b.w.) and high (100 μg/kg b.w.) doses of mycotoxin-zearalenone on selected blood serum enzyme activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), and total lactatedehydrogenase (LD) of rabbits were studied. The toxin was administered orally for 14 days. In the experimental group E 1 (10 μg/kg b.w.), a significant increase in ALP activity was observed at 168 and 336 h during the experiment. In the 100 μg zearalenone sera (group E 2), significant increases in activities of AST, ALT, ALP, GGT, and LD were observed at 168 and 336 h, indicating possible liver toxicity due to chronic effects of the toxin.