Abstract
1. 1. The effect of x-ray exposure on DNase II activity of the spleen, thymus, liver, and kidney has been studied in normal rats and in rats pretreated with cysteine. The twofold increase in specific enzyme activity of the lymphoid organs noted one day after irradiation was not influenced by pretreating rats with cysteine. 2. 2. Assay of the spleen and thymus for enzyme activity, DNA, and acid-soluble diphenylamine-reactive substances shows that the progressive increase with time in enzyme activity per milligram wet weight of the radiosensitive organs is correlated with a decrease in DNA concentration. An increase in acid-soluble diphenylamine-reactive substance believed to be composed largely of deoxypentose derivatives was observed in these tissues one day after exposure. These results are believed to indicate that the rate of DNA catabolism was increased. 3. 3. The DNase II activity per milligram wet tissue was observed to be essentially the same in the pulp and connective tissue fractions of normal spleen and thymus. A comparable increase in both fractions was observed after irradiation. 4. 4. No change in the hypothetical tissue inhibitor or activator was demonstrated.
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