Abstract
The effects of consuming freeze‐dried, whole‐grape powder (GP) or a placebo powder (P) for 12 weeks on body composition, biomarkers of inflammation, adipose tissue, and bone metabolism were determined. A randomized, double‐blind, placebo‐controlled study was performed with 40 post‐menopausal women (mean age 52.4±7.4) from 16 cities in Texas. Body composition and bone mineral densities (BMD) were determined using dual‐energy X‐ray absorptiometry (DXA). Serum concentrations of cross‐linked N‐telopeptide of type I collagen (NTX), alkaline phosphatase (ALP), osteocalcin (OC), insulin‐like growth factor‐1 (IGF‐1), adiponectin, leptin, prostaglandin E2 (PGE2), and leukotriene E4 (LTE4) were assayed using ELISA. Participants BMD were within normal ranges at baseline and at the end of study. NTX (p=0.04) and ALP (p=0.04) were significantly different between groups at baseline. In the placebo group (n=14), OC (p<0.01), adiponectin (p=0.01), and LTE4 (p=0.02) significantly decreased by 60.6%, 45.8%, and 61.9%, respectively. OC (p=0.02) and adiponectin (p=0.02) significantly decreased in GP group (n=11) by 50.9% and 59.7%, respectively. There were no significant differences between groups at 12 weeks. In the short term, freeze‐dried whole‐grape powder may exert no favorable effects on bone or adipose tissue biomarkers in post‐menopausal women.Grant Funding Source: California Table Grape Commission.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
