Abstract
An oral progestogen - R 2323 - was given in the dose of 10 mg as a weekly contraceptive pill. The effect on the ovarian function was followed by measuring the plasma levels of progesterone and estradiol. Seventeen cycles were studied and, in three of these, ovulation occurred. In all other cycles, progesterone and estradiol were depressed to early follicular phase levels. Intermenstrual bleeding or spotting was noticed in all cycles except the ovulatory ones. It is concluded that R 2323 in this dosage probably gives a better contraceptive effect than lower dosages. The occurrence of intermenstrual bleeding and spotting seems to be related to the timing of drug intake.
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