Abstract
BackgroundFluralaner spot-on solution provides immediate and persistent efficacy against tick and flea infestations in dogs and cats for 12-weeks following topical administration. The active ingredient fluralaner is distributed systemically following transdermal absorption. Therefore, this study tested the hypothesis whether water-immersion or shampooing of dogs following administration of fluralaner spot-on solution has an impact on subsequent tick and flea efficacy.MethodsThirty-two Beagle dogs were allocated to four study groups of 8 dogs each. On day 0, dogs in the 2 treatment groups received topical administration of fluralaner (Bravecto™ spot-on solution) according to label instructions. Dogs in the 2 corresponding control groups remained untreated. On days 3, 21, 49, and 77 dogs in one treatment group and control group were water-immersed for 2–5 min, while dogs in the other treatment group and control group were shampooed 6–8 min with a commercial foaming micro-emulsion, unscented product. On days 4, 28, 56, and 84 all dogs were co-infested with 50 ± 2 female and 10 ± 2 male Ixodes ricinus and 100 ± 4 Ctenocephalides felis, with tick and flea removal and counts 48 ± 2 h post-infestation. Efficacy against ticks and fleas was calculated for each assessment time point.ResultsNo treatment-related adverse event was observed in any of the 16 dogs treated with fluralaner spot-on solution during the study.Efficacy against ticks at each assessment time point was between 99.7 and 100 % in the water-immersed group and between 99.2 and 100 % in the shampooed group. Efficacy against fleas was 100 % at each assessment time point as well in the water-immersed as the shampooed group. Tick and flea reduction in both treatment groups was significant at all assessment time points (p < 0.0001).ConclusionsNeither water-immersion nor shampooing after single topical administration of fluralaner spot-on solution had an impact on the excellent tick and flea efficacy over the 12-week recommended re-treatment interval.
Highlights
Fluralaner spot-on solution provides immediate and persistent efficacy against tick and flea infestations in dogs and cats for 12-weeks following topical administration
For a topically administered ectoparasiticide it is important to ensure that the treatment maintains its effectiveness over the entire recommended treatment interval including the possibility of repeated water-immersion or shampooing
Results from this study demonstrate that a single topical fluralaner spot-on solution administration remains highly effective against ticks and fleas for 12 weeks following treatment even in the face of repeated waterimmersion or shampooing of the dog
Summary
Fluralaner spot-on solution provides immediate and persistent efficacy against tick and flea infestations in dogs and cats for 12-weeks following topical administration. This study tested the hypothesis whether water-immersion or shampooing of dogs following administration of fluralaner spot-on solution has an impact on subsequent tick and flea efficacy. Ticks and fleas are the most important ectoparasites infesting dogs worldwide. They cause discomfort and blood loss for infested dogs and create concerns for owners when their pets are infested. There is risk for During the last decade the number of products and strategies available for tick and flea control increased remarkably, e.g. by combining several active ingredients into one formulation to broaden the anti-parasitic spectrum, or presenting different routes of administration, including. For a topically administered ectoparasiticide it is important to ensure that the treatment maintains its effectiveness over the entire recommended treatment interval including the possibility of repeated water-immersion or shampooing
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