Abstract
Beraprost sodium is a chemically stable PGI2 analog which has antiplatelet and vasodilating properties, its ability to improve survival after prolonged ischemia was tested on the rat epigastric island flap. Forty Sprague-Dawley rats were divided into control (Ringer's lactated) and treated (beraprost sodium) groups and subdivided into two groups of total ischemia (both artery and vein were occluded): 11 and 15 h. After the ischemic period the flaps were slowly perfused with 4 ml of beraprost sodium solution or R/L solution. After seven days the survival areas were documented: Goup 1 (control — 11 h of ischemia): 9.9%; Group 2 (beraprost sodium — 11 h of ischemia): 85.9%; Group 3 (control — 15 h of ischemia): 0%; Group 4 (beraprost sodium — 15 h of ischemia): 48.2%. Using the student's t-test the result demonstrated that beraprost sodium improved flap survival in both the 11 and 15 h of ischemia groups (p<0.005).
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