Abstract
Small variations in scatterer volume fraction, which can result from changes in tissue microstructure due to cancer therapies or organ preservation, may have a significant impact on ultrasound backscatter. Although the effect of volume fraction has been studied for non-biological scatterers and red blood cells, this study addresses the case of nucleated cells. Suspensions with volume fractions up to 70% of acute myeloid leukemia cells were insonified with broadband 20 MHz and 40 MHz pulses. The resultant average normalized backscatter intensities plotted as a function of volume fraction demonstrated a better agreement with the Yagi-Nakayama continuum scattering theory rather than the Mo-Cobbold particle scattering model (using hard sphere packing). Normalized backscatter increased with cell volume fraction up to a maximum value, occurring between 20 and 30% volume fraction, varying with frequency and then decreased with further increases in volume fraction. This result may have implications in the development of new quantitative, ultrasound-based tissue characterization techniques.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
