Abstract
Background. According to WHO data (2014), more than two billion people are deficient in microelements or have a “hidden hunger” due to the deficiencies of vitamins and minerals. Currently, experts estimate the vitamin D deficiency as a new type of pandemic of the XXI century.
 Aim. The current analysis was undertaken to evaluate the effect of vitamin D on women’s reproductive health.
 Materials and Methods. Based on the findings of retrospective and prospective studies, meta-analyzes, and material trials over the past 20 years, as well as in accordance with the results of 290 prospective cohort randomized trials, the level of vitamin D affects 172 basic physiological indicators associated with the risk of such complications of pregnancy as miscarriage, preeclampsia, gestational diabetes mellitus, and bacterial vaginosis.
 Results. Vitamin D has been shown to be able to act as an immune regulator during the implantation. The placenta produces and responds to vitamin D, which has a local anti-inflammatory response and simultaneously induces the production of decidual growth factors for successful pregnancy. Activated T- and B-lymphocytes have the vitamin D receptors and therefore 1,25(OH)2D is an effective modulator in the immune system. It is able to inhibit the proliferation of Th1 and to restrict the production of such cytokines as interferon-gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor-alpha (TNF-α). In addition, vitamin D is able to induce cytokines of Th2 that have the protective effect on pregnancy.
 Conclusion. Adequate vitamin D intake is important for the successful conception and prolongation of pregnancy, as well as for the health of the fetus and newborn.
Highlights
According to WHO data (2014), more than two billion people are deficient in microelements or have a “hidden hunger” due to the deficiencies of vitamins and minerals
Vitamin D has been shown to be able to act as an immune regulator during the implantation
Activated T- and B-lymphocytes have the vitamin D receptors and 1,25(OH)2D is an effective modulator in the immune system
Summary
Влияние витамина D на репродуктивное здоровье женщины // Журнал акушерства и женских болезней. В настоящее время эксперты оценивают дефицит витамина D как новую пандемию XXI в. Цель — изучить влияние витамина D на репродуктивное здоровье женщины. На основе полученных данных ретроспективных и проспективных исследований, метаанализов, материала работ за последние 20 лет и согласно результатам 290 проспективных когортных рандомизированных исследований было проанализировано влияние витамина D на репродуктивное здоровье женщины. Aim. The current analysis was undertaken to evaluate the effect of vitamin D on women’s reproductive health. Based on the findings of retrospective and prospective studies, meta-analyzes, and material trials over the past 20 years, as well as in accordance with the results of 290 prospective cohort randomized trials, the Журнал акушерства и женских болезней Journal of Obstetrics and Women’s Diseases
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