The Effect of Vitamin D, B12, and Folic Acid Supplements in Relieving Major Depressive Symptoms, General Anxiety Disorder among Adults and Adolescents - A Systemic Article Review

Abstract

Depression and anxiety disordersare a heterogeneous disorders and are thought to develop as a result of complex interactions between genetic and environmental Factors.(1) Vitamin D deficiency is the most common cause of Osteomalacia among adults and adolescents with its associated classical symptoms such as bones pain, muscle weakness which may affect productivity, daily activates, school and work absence and mood. Vitamin B12 deficiency causes complex hematological and neurological signs and symptoms as easy fatigability, lethargy, pallor, ictrous, paresthesia, difficulty of balance or loss of proprioception and neuropsychiatric symptoms may be presented in severe cases. Vitamin B9 deficiency is a rare condition causes complex hematological signs and symptoms as easy fatigability, lethargy, pallor, ictrous, symptoms may be presented in severe cases. Aim of the study: To review articles studying the relationship between Vitamin D deficiency and/ or vitamin B12 deficiency, and/or B9 deficiency levels and supplements in relieving major depression (MDD) and general anxiety disorder (GAD) symptoms.