Abstract
Context: Automobile workers (AMWs) are exposed to lots of toxic chemicals with associated adverse health consequences. The adverse health effects are mainly attributed to oxidative stress, however, antioxidant vitamins may aid in ameliorating these adverse effects. Aim: The aim of this study was to examine the effect of Vitamin C supplementation on toxic metals, antioxidant minerals, oxidative stress, and lipid profile of AMWs. Settings and Design: Twenty-nine AMWs and 30 controls aged 19–55 years were recruited for this study. Subsequently, 27 AMWs received 500 mg Vitamin C tablets daily for 2 months. Subjects and Methods: Five milliliters of fasting blood samples was collected before intervention and at 1- and 2-month intervals for biochemical analyses. Blood lead (Pb), cadmium (Cd), selenium (Se), and zinc (Zn) were analyzed using atomic absorption spectrophotometer, malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured spectrophotometrically, total cholesterol (TC), high-density lipoprotein (HDL), and triglyceride (TG) were measured enzymatically, whereas MDA/TAC, low-density lipoprotein (LDL), very LDL (VLDL), and non-HDL (nHDL) were calculated. Statistical Analysis: Data were analyzed, and statistical significance was set at P
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