Abstract
THE EFFECT OF VITAMIN B12 ON RAT GROWTH AND FAT INFILTRATION OF THE LIVER
Highlights
If the decrease in the liver lipides found in rats fed vitamin B12 on the homocystine diet indicates a synthesis of choline, we can conclude that the low amount of liver lipides found in the control group of the methionine experiment, in spite of the absence of dietary vitamin B12, indicates a demethylation of methionine and a synthesis of choline
Crystalline vitamin B1, or equivalent amounts of this vitamin, fed in the form of liver and animal protein preparations, will enable rats to grow at practically identical rates on a “labile methyl”-free homocystine diet containing folic acid and to maintain normal livers
These findings indicate that vitamin Blz is the principal, if not the sole, factor in these preparations responsible for the observed growth
Summary
Addition of less refined liver extracts to the “labile methyl”-free diet enabled our rats to utilize homocystine for growth [3] It would seem, that vitamin Blz was the active factor in these earlier preparations as well. The present experiments were undertaken in an attempt to find out whether vitamin B,z is the sole factor, in the various liver preparations, which is responsiblefor the growth of our rats on the “labile methyl”-free homocystine diet. To test this possibility, it was planned to feed to rats several different liver preparations and an animal protein factor in doses containing equivalent amounts of vitamin Blz. The vitamin Blz content of the various preparations was determined by microbiological assay.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
