Abstract
Diabetes is associated with an increase in other chronic diseases and an increase in mortality. The individual differences influence the treatment of this disease in pharmacokinetics and clinical responses. One of the important factors related to individual differences includes genetic factors in transmission, metabolism, and drug function. On the other hand, this disease has a significant impact on the patients' quality of life and their family. Therefore, this study aimed to investigate the role of single nucleotide polymorphism (rs2110385) of the visfatin gene on insulin required to maintain glucose homeostasis and to evaluate the effect of insulin pump therapy on the quality of life in type 1 diabetic patients. In this regard, this study was performed on 47 patients with type 1 diabetes. The short form of the Diabetes Quality of Life Questionnaire (DQOL) was used to record information. Laboratory tests also included FBS, HbA1C, G2h, serum levels of visfatin, insulin, and adiponectin. Insulin resistance (HOMA) and insulin sensitivity (QUICKI) indices were calculated. The polymorphism of the studied genotype was performed by the PCR-RFLP method. The results showed that the scores of both dimensions of quality of life, including patient care behaviors and satisfaction with the disease control after the intervention increased significantly (P <0.001). There was a significant and direct relationship between the patient's age and the duration of the disease with the score of increasing patients' quality of life. No significant differences were found between HbA1C, G2h, FBS levels, fasting insulin concentration, HOMA, and QUICKI indices. The insulin dose used to maintain glucose homeostasis at the same levels was significantly lower in the GG genotype than in other genotypes. In general, the present study results showed that insulin pump therapy and its dimensions could improve the life quality of patients with type 1 diabetes. Also, genetic evaluation of individuals helps to provide the correct and accurate dose of insulin with the help of the insulin pump for these patients to increase their quality of life as much as possible.
Highlights
The questionnaire consisted of questions about personal factors and the short form of the Diabetes Quality of Life Questionnaire (DQOL)
One of the objectives of this study is to evaluate the effect of insulin pump therapy on the quality of life of patients with type 1 diabetes
This study showed that the mean of life quality scores and dimensions of type 1 diabetes patients after the study were significantly improved compared to before the study
Summary
It can Decreased quality of life reduces care, inadequate lead to vascular disorders, kidney failure, amputation, blood sugar control, and increases the risk of blindness, neurological diseases, dental diseases, complications [5]. Diabetes can impair the life quality of through repeated daily insulin injections, blood the patient, their family, and their companions. Diabetes can threaten a treatment is a method that improves the patient's person's independence and give a different feeling quality of life in addition to controlling blood sugar from others, which can cause stress.
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