Abstract
The purpose of the present investigation was to evaluate the effectiveness of different vehicles on drug permeability and microstructure of intercellular or lipids in SC layer of skin. Pre-treated skin of rat using some vehicles including Labarac PG ,Transcutol P, tween 80, span 80 and propylene glycol (PG), were mounted on specialized design franz-diffusion cell was used to assess naproxen permeation and parameters such as permeability coefficients and state flux (Jss) were evaluated. Any differences in peak position and also change in symmetric and asymmetric stretching of C-H bond, lipid ester carbonyl stretching in SC, C=O stretching (Amide I) and C-N stretching of keratin (Amide II) absorbance using Fourier transform infrared spectroscopy (FTIR) were considered to investigate the enhancing mechanism. DSC method was utilized to compare their mean transition temperature (Tm) and enthalpies (ΔH). Steady-state flux (Jss), permeability coefficient (Kp) and diffusion coefficient (D) were significantly (p<0.05) increased by using their span80 showed the biggest enhancement ratio (ERflux) and Transcutol P, Labrafac PG, Tween 80 and Propylene glycol were at the next levels. In comprised to hydrated rat skin the maximum increase in diffusion coefficient was for Tween 80(p<0.05), Lipid fluidization, lipid disruption structure and the irreversible denaturation of proteins in the SC layer of skin by span 80, Tween 80, Labrafac PG, Transcutol P and propylene glycol, were indicated by FT-IR and DSC techniques. It is concluded that naproxen permeation through rat skin may be facilitated by utilizing the vehicle systems. Lipid fluidization and lipid extraction are among suggested mechanisms.
Highlights
Nowadays, dermal delivery of drugs is considered as an important way for administration of drugs
To recognize the mechanism by which the properties of enhancers/retardants change in a given vehicle, molecular studies of whole rat skin was carried out using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR)
The study was aimed to evaluate the effectiveness of some hydrophobic and hydrophilic vehicles on naproxen in vitro skin permeability of through Excised Whole Rat Skin and the study of biophysical characteristics of Rats’ stratum corneum by Fourier transform infrared spectroscopy (FT-IR) and DSC techniques in order to design a new drug delivery system for skin delivery of naproxen
Summary
Dermal delivery of drugs is considered as an important way for administration of drugs. To reduce the risk of gastric irritation and toxicity, and to gain a more effective therapy, transdermal administration is a promising route It enables sustained and controlled release of drugs and increases patient compliance.[20] The study was aimed to evaluate the effectiveness of some hydrophobic and hydrophilic vehicles on naproxen in vitro skin permeability of through Excised Whole Rat Skin and the study of biophysical characteristics of Rats’ stratum corneum by FT-IR and DSC techniques in order to design a new drug delivery system for skin delivery of naproxen
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
