Abstract
The effect of the inclusion of several concentrations of surface-active agents in four different types of ointment bases on the percutaneous absorption of salicylic acid and sodium salicylate was determined. Hydrophilic ointment, petrolatum, hydrophilic petrolatum containing water, and polyethylene glycol ointment were modified either by varying the concentration of surface-active agent present in the U. S. P. XV formula, or by adding varying amounts of surface-active agents to those bases in which none was originally present. Sorbitan monostearate, polyoxyethylene 20 sorbitan monostearate, and polyoxyethylene 40 stearate were studied as representative of lipophilic and hydrophilic surface-active agents of the nonionic type. The results indicate a correlation between percutaneous absorption and the degree of interaction of the polyoxyethylene groups present in the hydrophilic surface-active agents with the salicylates.
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