Abstract
The effect of variations in LET and cell cycle on radiation carcinogenesis was studied in ${\rm LAF}_{1}/\text{Jax}$ mouse liver. Our results are consistent with those of Cole and Nowell in that both the quality (LET) of the radiation and the addition of a proliferative stimulus significantly alter the hepatocarcinogenic endpoint. A single, whole-body, 200-rad dose of137 Cs gamma rays increased the hepatoma incidence by approximately 3- to 4-fold over the control rates, when a pure proliferative stimulus (partial hepatectomy) was added. Also a single, whole-body, 200-rad dose of fission neutron irradiation increased the hepatoma incidence by approximately 6 -to 9-fold over the control rate, when combined with partial hepatectomy. Furthermore, both the137 Cs and fission neutron hepatocarcinogenic rates were enhanced regardless of whether the irradiation was given either during liver regeneration or 8-13 weeks prior to partial hepatectomy. However, neither137 Cs nor fission neutron irradiation alone (i.e., ...
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