The Effect of Variations Concentration of Chloramphenicol on the Imprinting Factor of Molecularly Imprinted Polymer

Abstract

This research aimed is to determine the effect of chloramphenicol concentration on the imprinting factor (IF) value of the Molecular Imprinted Polymer (MIP). Imprinting Factor is a standard of the interaction power between printed polymer and template molecule. The IF value was calculated based on the adsorption capacity value between MIP and blank polymer (BP). MIP was synthesized from non-imprinted polymer (NIP) using the precipitation method with chloramphenicol as a template, methacrylic acid (MAA) as a monomer, and ethylene glycol dimethacrylate (EGDMA) as a crosslinker. The results showed that the optimum concentration was at 10 ppm with the IF value of 5,005. The isothermal adsorption result of Chloramphenicol using MIP can best be described by the Langmuir model. The limit of detection (LOD) value was 0.098 and the limit of quantification (LOQ) value was 0.327.