The effect of Varenicline on Betel nut dependence in Albino wistar rats

Abstract

Betel nut is one of the most common addictive substance. Not many studies have explored the potential of varenicline as cessation therapy. We studied the benefits of varenicline in reducing the reward effects in rat model. Forty male albino rats of wistar strain weighing 150-250grams were used in the present study. Rats were randomized to 5 groups of 8 rats each to: Control; Betel nut group; Varenicline at doses of 0.5, 1 and 2mg/kg along with betel nut. Conditioned Place Preference (CPP) model was used for studying the drug seeking behavior. The CPP score was compared between the groups. Results showed a significant increase in body weight of rats at the end of the study compared to baseline in betel nut and varenicline groups. Compared to betel nut group (656.25±55) there was significant decrease in CPP score in Varenicline group at 0.5mg/kg (97.5±48); 1mg/kg (18.75±20) and at dose of 2mg/kg (-60±6). The study demonstrates the benefits of varenicline in betelnut dependence. There was dose dependent decrease in betel nut seeking behavior with varenicline in rat model of drug dependence.