The Effect of Uric Acid and Albumin Ratio in Undergoing Lower Extremity Endovascular İnterventions For Peripheral Arterial Disease Related Contrast Induced Nephropathy

Abstract

Among patients undergoing percutaneous vascular intervention, contrast-induced nephropathy (CIN) is associated with increased morbidity and mortality.Serum uric acid/albumin ratio (UAR) has emerged as a new marker associated with poor cardiovascular outcomes. We aimed to evaluate the relationship between UAR and CIN occurrence in patients treated for peripheral artery disease. Patients underwent percutaneous intervention due to peripheral artery disease were enrolled. The primary endpoint was development of contrast related nephropathy. Patients were divided into two groups according to the CIN occurrence. 663 patients were enrolled and mean age was 62±10 years. After the intervention, 45 patients had CIN and 618 patients did not have CIN. Logistic regression analysis were performed to define the parameters of CIN. Male gender, diabetes, uric acid /albumin ratio, contrast volume, presence of coronary artery disease and CRP levels were found significant in univariate analysis. However, only UAR was found significant in multivariate analysis (OR 95% CI: 3.426 (1.059-11.079), (p=0.040)).Therefore ,it is the only independent predictor for occurrence of CIN. UAR is a reliable scoring system, which predicts CIN in such patient group. This score is not only cost-effective also simple, which can be easily applied into the clinical practice.