Abstract
Urethane does not cause protective effect in experimentally induced typhoid fever intoxication. Prolonged use of urethane in the doses of 20 mg per mouse, weighing 17–18 kg; decreases the resistance of the animals to subsequent bacterial intoxication. Subcutaneous introduction of urethane in the dose of 0.5 mg per mouse during 3 or 4 days results in decrease of the weight of the thymus gland, while the dose of 10 to 15 mg causes reduction in the weight of the spleen. This effect is reached both in normal mice and in adrenalectomized ones.
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