Abstract
Unripe dates are believed by Indonesian citizens to increase fertility. This study aimed to assess the effect of unripe dates in the ovary of rats. Fresh yellow-colored dates were dried in an oven and crushed into powder. Eighteen rats aged three months and had given birth once were randomly divided into three groups. The treatment groups were given unripe dates at doses of 160mg/kgBW and 320mg/kgBW through a feeding tube for 28 days, and the control group was only given distilled water. Histopathological examination was carried out by the pathology expert using Hematoxylin-Eosin staining to observe the number of ovarian follicles according to their maturation stage. The results showed that the administration of unripe dates powder 320mg/kgBW increased corpus luteum number (21.50±4.72) and was statistically significant compared to the control group (15.16±3.71). Similar differences were also found in other stages of the follicle although not statistically significant. Administration of unripe date powder can increase ovulation induction among fertile rats.
Highlights
Infertility is defined as the inability to obtain pregnancy after one year of regular intercourse without contraception [1]
The number of secondary and tertiary follicles in the group treated with an unripe date at a dose of 320mg/kgBW was higher than control group, not statistically significant
This study showed that the treatment groups had a higher number of secondary and tertiary follicles than the control group
Summary
Infertility is defined as the inability to obtain pregnancy after one year of regular intercourse without contraception [1]. Infertility prevalence is highest in South Asia, Sub Saharan African, North Africa/Middle East, Central/East Europe, and Central Asia [2]. Infertility prevalence in Indonesia is about 15-20% in 2009 [3]. Infertility may arise from male factors, female factors, or both. Female infertility factors contribute to approximately 50% of all infertility cases caused by ovulation disorders, uterine abnormalities, tubal obstruction, and peritoneal factors [1]. Anovulation accounts for 25-50% of the causes of female infertility [4]. Infertility can cause a psychological problem, such as anxiety and depression [5]. About 80% of couples tried out traditional medicine for their infertility since it is available, cheap, and has a variety of health benefits [6,7]
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