The Effect of TYPE 1 DIABETES ON REPRODUCTIVE HORMONES (FOLLICLE STIMULATING, LUTEINIZING AND TESTOSTERONE HORMONES) IN HUMAN MALE SUBJECTS

Abstract

Diabetes mellitus is a syndrome characterized by chronic hyperglycemia (high blood sugar) either because the body does not produce enough insulin (Type 1 or Insulin Dependent Diabetes Mellitus‐IDDM), or because body cells do not properly respond to insulin that is produced (Type 2 or Non Insulin Dependent Diabetes Mellitus‐NIDDM).Diabetes Mellitus has been recognized as a clinical syndrome since ancient times and remain a crippling global health problem till today (Wild et al.,2004).This study was designed to determine the effect of Type 1 diabetes on reproductive hormones (Luteinizing hormone (LH), Follicle Stimulating Hormone (FSH) and Testosterone Hormone (TH) in human male subjects. Forty (40) human male subjects were used for the purpose of this experiment and were grouped into two ;Control group consisting of twenty (20) healthy subjects (confirmed non‐diabetic with fasting blood glucose level of < 110mg\dl) and the Experimental group consisting of 20 Type 1 diabetic patients. Blood samples were collected and immunoassay analyses were carried out to determine the levels of plasma FSH, LH and TH.The results from this study showed significant reductions ( p<0.05) in the levels of FSH, LH and TH in the diabetic group when compared with the control or non‐diabetic group confirming that diabetic condition affects reproductive activities negatively.