Abstract
The effect of two diphosphonate compounds on calcium handling in rat kidney mitochondria has been studiedin vitro. Initial calcium uptake in the presence of an oxidisable substrate and ATP was not influenced by either diphosphonate tested. The release of accumulated calcium from the mitochondria was, however, delayed by these compounds and the effect was found to be dose dependent. Similarily, a second uptake of calcium, induced by re-addition of ATP following preliminary release, was also modified by diphosphonates, the mitochondrial suspensions incubated with diphosphonates accumulating more calcium than control suspensions. The effect of these compounds could not be detected on three mitochondrial ATPase systems. The results have been discussed in relation to knownin vivo effects of diphosphonates.
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